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Vitamin B12 Essentials 2.1 Biochemical Roles and Neurological Importance Vitamin B12 (cobalamin) is indispensable for two biochemical pathways: Methionine Synthase : Converts homocysteine to methionine, fueling methylation reactions vital for DNA synthesis, neurotransmitter production (serotonin, dopamine), and myelin maintenance

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607 The iron uptake inhibitor ferristatin II provides neuroprotection by suppressing ferroptosis, and HBED treatment alleviates secondary damage after TBI by binding to Fe 2+ and converting Fe 2+ to Fe 3+

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